Laboratory of Immune Molecular Function, Faculty of Science & Engineering,
Kindai University





Publications

Original papers

  1. Lysophosphatidic acid (LPA) receptor-mediated signaling regulates hypoxia-induced biological functions of lymphatic endothelial cells Yamamoto M, Takai M, Yashiro N, Hayasaka H, Tsujiuchi T. Biochem. Biophys. Res. Commun. (2024) DOI: 10.1016/j.bbrc.2024.149982.
  2. Endogenous CCL21-Ser deficiency reduces B16-F10 melanoma growth by enhanced antitumor immunity. Fujie R, Kurowarabe K, Yamada Y, Fujiwara K, Nakatani H, Tsutsumi K, Hayashi R, Kawahata H, Miyamoto M, Ozawa M, Katakai T, Takahama Y, Ohigashi I, *Hayasaka H. Heliyon (2023) https://doi.org/10.1016/j.heliyon.2023.e19215
  3. CCL21-Ser expression in melanoma cells recruits CCR7+ naïve T cells to tumor tissues and promotes tumor growth. Miyamoto M, Kawato Y, Fujie R, Kurowarabe K, Fujiwara K, Nobusawa R, Hayashi R, Iida K, Ohigashi I, *Hayasaka H. Cancer Sci. (2023) https://doi.org/10.1111/cas.15902
  4. A CCR4 antagonist attenuates atopic dermatitis-like skin inflammation by inhibiting the recruitment and expansion of Th2 cells and Th17 cells. Sato M, Matsuo K, Susami Y, Yamashita A, Hayasaka H, Hara Y, Nishiwaki K, Oiso N, Kawada A, Otsuka A, Nakayama T. Int. Immunol. (2023) https://doi.org/10.1093/intimm/dxad019
  5. Identification of a novel type of focal adhesion remodelling via FAK/FRNK replacement, and its contribution to cancer progression. Tsujioka　M, Miyazawa K, Ohmuraya M, Nibe Y, Shirokawa T, Hayasaka H, Mizushima T, Fukuma T, Shimizu S. Cell Death & Disease (2023) DOI: 10.1038/s41419-023-05774-4
  6. Firefly luciferase-based chronological measurement of effector CD8 T cell activity using a multi-chamber luminometer. Hayashi R, Nakatani H, Kawahata H, Fujie R, Kurowarabe K, *Hayasaka H. Bioanalysis (2023) https://www.future-science.com/doi/10.4155/bio-2022-0208
  7. Dach1 transcription factor regulates the expression of peripheral node addressin and lymphocyte trafficking in lymph nodes. Shintani A, Fukai S, Nobusawa R, Taniguchi K, Hatatani T, Nagai H, Sakai T, Yoshimura T, Miyasaka M. *Hayasaka H. Cur. Res. Immunol. (2022) https://doi.org/10.1016/j.crimmu.2022.08.008
  8. CXCL12 promotes CCR7 ligand-mediated breast cancer cell invasion and migration toward lymphatic vessels. *Hayasaka H, Yoshida J, Kuroda Y, Nishiguchi A, Matsusaki M, Kishimoto K, Nishimura H, Okada M, Shimomura Y, Kobayashi D, Shimazu Y, Taya Y, Akashi M, Miyasaka M.　Cancer Sci.　(2022) https://doi.org/10.1111/cas.15293
  9. Extracellular ATP limits homeostatic T cell migration within lymph nodes. Kobayashi D, Sugiura Y, Umemoto E, Takeda A, Ueta H, Hayasaka H, Matsuzaki S, Katakai T, Suematsu M, Hamachi I, Yagutkin GG, Salmi M, Jalkanen S, Miyasaka M. Front. Immunol. (2021) https://www.frontiersin.org/articles/10.3389/fimmu.2021.786595/full
  10. CXCL12-stimulated lymphocytes produce secondary stimulants that affect the surrounding cell chemotaxis. Kurowarabe K, Endo M, Kobayashi D, *Hayasaka H. Biochem. Biophys. Rep. (2021) https://doi.org/10.1016/j.bbrep.2021.101128
  11. Endogenous membrane receptors labeling by reactive cytokines/growth factors to chase their dynamics in live cells.Takaoka Y, Uchinomiya S, Kobayashi D, Endo M, Hayashi T, Fukuyama Y, Hayasaka H, Miyasaka M, Ueda T, Shimada I, Hamachi I.Chem (2018) https://doi.org/10.1016/j.chempr.2018.03.021
  12. Regulation of CCR7-dependent cell migration through CCR7 homodimer formation.Kobayashi D, Endo M, Ochi H, Hojo H, Miyasaka M, *Hayasaka H. Scientific Reports, doi:10.1038/s41598-017-09113-4（2017）https://www.nature.com/articles/s41598-017-09113-4
    English→　KINDAI HP
  13. Fibroblastic reticular cell-derived lysophosphatidic acid regulates confined intranodal T-cell motility. Takeda A, Kobayashi D, Aoi K, Sasaki N, Sugiura Y, Igarashi H, Tohya K, Inoue A, Hata E, Akahoshi N, Hayasaka H, Kikuta J, Scandella E, Ludewig B, Ishii S, Aoki J, Suematsu M, Ishii M, Takeda K, Jalkanen S, Miyasaka M, Umemoto E. eLife （2016）http://dx.doi.org/10.7554/eLife.10561
  14. The HIV-1 gp120/CXCR4 axis promotes CCR7 ligand-dependent CD4 T cell migration: CCR7 homo- and CCR7/CXCR4 hetero-oligomer formation as a possible mechanism for up-regulation of functional CCR7. Hayasaka, H., Kobayashi, D., Yoshimura, H., Nakayama, E.E., Shioda, T., Miyasaka, M. PLoS ONE,１０：e0117454. (2015)
  15. Lysophosphatidic acid receptors LPA4 and LPA6 differentially promote lymphocyte transmigration across high endothelial venules in lymph nodes. Hata, E., Sasaki N., Takeda A., Tohya K., Umemoto E., Akahoshi N., Ishii S., Bando K., Abe T., Kano K., Aoki JH., Hayasaka H., Miyasaka M. Int. Immunol., doi: 10.1093/intimm/dxv072 (2015)
  16. Dynamic changes in endothelial cell adhesion molecule nepmucin/CD300LG expression under physiological and pathological conditions. Umemoto, E., Takeda, A., Jin, S., Luo, Z., Nakahogi, N., Hayasaka, H., Lee, CM., Tanaka, T., Miyasaka, M. PLoS ONE, 8: e83681 (2013)
  17. FAK-related nonkinase is a multifunctional negative regulator of pulmonary fibrosis. Ding, Q., Cai, G-Q., Hu, M., Yang, Y., Zheng, A., Tang, Q., Gladson, CL., Hayasaka, H., Wu, H., You, Z., Southern, BD., Grove, LM., Rahaman, SO., Fang,H., Olman, MA. Am. J. Pathol., 182: 1572-1584. (2013)
  18. Constitutive lymphocyte transmigration across the basal lamina of high endothelial venules is regulated by the autotaxin/lysophosphatidic acid axis. Bai, Z., Cai, L., Umemoto, E., Takeda, A., Tohya, K., Komai, Y., Veeraveedu, PT., Hata, E., Sugiura, Y., Kubo, A., Suematsu, M., Hayasaka, H., Okudaira, S., Aoki, J., Tanaka T., Albers, HMHG., Ovaa, H., Miyasaka, M. J. Immunol., 190: 2036-2048. (2013)
  19. Constitutive plasmacytoid dendritic cell migration to the splenic white pulp is cooperatively regulated by CCR7- and CXCR4-mediated signaling. Umemoto, E., Otani, K Ikeno, T., Verjan Garcia N, Hayasaka, H., Bai, Z., Jang MH., Tanaka T., Ueda, K., Miyasaka, M. J. Immunol., 189: 191-199. (2012)
  20. Two-state conformations in the hyaluronan-binding domain regulate CD44 adhesiveness under flow condition. Ogino, S., Nishida, N., Umemoto, R., Suzuki, M., Takeda, M., Terasawa, H., Kitayama, J., Matsumoto, M., Hayasaka, H., Miyasaka, M., Shimada, I. Structure., 18: 649-656. (2010)

Review and Bulletin (English and Japanese)

  1. Nishizawa H, Kurowarabe K, Hayashi R, Hayasaka H.：Real-time monitoring of B16 melanoma cell viability by the firefly luciferase-based bioluminescence.　Science and technology 32：5-11. (2021)
  2. 早坂　晴子：哺乳動物細胞における可溶型リンフォトキシン受容体タンパク質の発現　　理工学総合研究所研究報告　31：55-61. (2020)
  3. Miyasaka M, Hata E, Tohya K, Hayasaka H. Lymphocyte recirculation. Encyclopedia of Immunobiol., 3:486-492. (2016)
  4. Kellermayer Z, Hayasaka H, Kajtár B, Simon D, Robles EF, Martinez-Climent JA, Balogh P
    Divergence of vascular specification in visceral lymphoid organs - genetic determinants and differentiation checkpoints.　Int. Rev. Immunol. 35: 489-502 (2016)
  5. Umemoto, E., Hayasaka, H., Bai, Z., Cai, L., Yonekura, S., Peng, X., Takeda, A., Tohya, K., Miyasaka, M. Novel regulators of lymphocyte trafficking across high endothelial venules. Crit. Rev. Immunol., 31: 147-169. (2011)
  6. Hayasaka, H., Taniguchi, K., Fukai, S. Miyasaka, M. Neogenesis and development of the high endothelial venules that mediate lymphocyte trafficking. Cancer Sci., 101: 2302-2308. (2010)
  7. 小林　大地、宮坂　昌之、早坂　晴子：ケモカイン受容体の協働作用による効率的なリンパ球移動の誘導(2013) 生体の科学 64: 398-399.
  8. 早坂　晴子、岡田　麻里、白　忠彬、黒田　康嵩、吉田　淳一、宮坂　昌之：ケモカインによる白血球、癌細胞の生体内移動調節とケモカイン共働作用の関与 生化学 83: 930-937.　(2011)
  9. 黒田　康嵩、宮坂　昌之、早坂　晴子：がんとリンフォイドケモカイン　侵襲と免疫　20: 38-39. (2011)
  10. 早坂　晴子、宮坂　昌之：癌の進展、転移に関与するリンフォイドケモカイン　実験医学［増刊］29: 119-124. (2011)
  11. 白忠彬、蔡林君、梅本英司、竹田彰、池野嵩、秦枝里奈、早坂晴子、宮坂昌之: リンパ球トラフィキングをつかさどる新しい分子機構ー生理活性脂質産生酵素オートタキシンとその産物リゾフォスファチジン酸の役割 炎症と免疫　19: 8-13. (2011)
  12. 白　忠彬、蔡　林君、梅本英司、早坂晴子、宮坂昌之: 血管内皮細胞が発現する生理活性脂質産生酵素オートタキシン 実験医学［増刊］28: 144-152. (2010)
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