近畿大学理工学部　生命科学科　免疫分子機能研究室

研究実績

原著論文 (*責任著者)

  1. Lysophosphatidic acid (LPA) receptor-mediated signaling regulates hypoxia-induced biological functions of lymphatic endothelial cells Yamamoto M, Takai M, Yashiro N, Hayasaka H, Tsujiuchi T. Biochemical and Biophysical Research Communications (2024) DOI: 10.1016/j.bbrc.2024.149982.
  2. Endogenous CCL21-Ser deficiency reduces B16-F10 melanoma growth by enhanced antitumor immunity. Fujie R, Kurowarabe K, Yamada Y, Fujiwara K, Nakatani H, Tsutsumi K, Hayashi R, Kawahata H, Miyamoto M, Ozawa M, Katakai T, Takahama Y, Ohigashi I, *Hayasaka H. Heliyon (2023) https://doi.org/10.1016/j.heliyon.2023.e19215
  3. CCL21-Ser expression in melanoma cells recruits CCR7+ naïve T cells to tumor tissues and promotes tumor growth. Miyamoto M, Kawato Y, Fujie R, Kurowarabe K, Fujiwara K, Nobusawa R, Hayashi R, Iida K, Ohigashi I, *Hayasaka H. Cancer Sci. (2023) https://doi.org/10.1111/cas.15902
    日本語解説→外部リンク
  4. A CCR4 antagonist attenuates atopic dermatitis-like skin inflammation by inhibiting the recruitment and expansion of Th2 cells and Th17 cells. Sato M, Matsuo K, Susami Y, Yamashita A, Hayasaka H, Hara Y, Nishiwaki K, Oiso N, Kawada A, Otsuka A, Nakayama T. Int. Immunol. (2023) https://doi.org/10.1093/intimm/dxad019
  5. Identification of a novel type of focal adhesion remodelling via FAK/FRNK replacement, and its contribution to cancer progression. Tsujioka　M, Miyazawa K, Ohmuraya M, Nibe Y, Shirokawa T, Hayasaka H, Mizushima T, Fukuma T, Shimizu S. Cell Death & Disease (2023) DOI: 10.1038/s41419-023-05774-4
  6. Firefly luciferase-based chronological measurement of effector CD8 T cell activity using a multi-chamber luminometer. Hayashi R, Nakatani H, Kawahata H, Fujie R, Kurowarabe K, *Hayasaka H. Bioanalysis (2023) https://www.future-science.com/doi/10.4155/bio-2022-0208
  7. Dach1 transcription factor regulates the expression of peripheral node addressin and lymphocyte trafficking in lymph nodes. Shintani A, Fukai S, Nobusawa R, Taniguchi K, Hatatani T, Nagai H, Sakai T, Yoshimura T, Miyasaka M. *Hayasaka H. Cur. Res. Immunol. (2022) https://doi.org/10.1016/j.crimmu.2022.08.008
    日本語解説→外部リンク
  8. CXCL12 promotes CCR7 ligand-mediated breast cancer cell invasion and migration toward lymphatic vessels. *Hayasaka H, Yoshida J, Kuroda Y, Nishiguchi A, Matsusaki M, Kishimoto K, Nishimura H, Okada M, Shimomura Y, Kobayashi D, Shimazu Y, Taya Y, Akashi M, Miyasaka M. Cancer Sci. (2022) https://doi.org/10.1111/cas.15293
    日本語解説→外部リンク
  9. Extracellular ATP limits homeostatic T cell migration within lymph nodes. Kobayashi D, Sugiura Y, Umemoto E, Takeda A, Ueta H, Hayasaka H, Matsuzaki S, Katakai T, Suematsu M, Hamachi I, Yagutkin GG, Salmi M, Jalkanen S, Miyasaka M. Front. Immunol. (2021) https://www.frontiersin.org/articles/10.3389/fimmu.2021.786595/full
  10. CXCL12-stimulated lymphocytes produce secondary stimulants that affect the surrounding cell chemotaxis. Kurowarabe K, Endo M, Kobayashi D, *Hayasaka H. Biochem. Biophys. Rep. (2021) https://doi.org/10.1016/j.bbrep.2021.101128
  11. Endogenous membrane receptors labeling by reactive cytokines/growth factors to chase their dynamics in live cells.Takaoka Y, Uchinomiya S, Kobayashi D, Endo M, Hayashi T, Fukuyama Y, Hayasaka H, Miyasaka M, Ueda T, Shimada I, Hamachi I. Chem (2018) https://doi.org/10.1016/j.chempr.2018.03.021
    日本語解説→PDFファイル
  12. Regulation of CCR7-dependent cell migration through CCR7 homodimer formation.Kobayashi D, Endo M, Ochi H, Hojo H, Miyasaka M, *Hayasaka H. Scientific Reports, doi:10.1038/s41598-017-09113-4（2017）https://www.nature.com/articles/s41598-017-09113-4
  13. Fibroblastic reticular cell-derived lysophosphatidic acid regulates confined intranodal T-cell motility. Takeda A, Kobayashi D, Aoi K, Sasaki N, Sugiura Y, Igarashi H, Tohya K, Inoue A, Hata E, Akahoshi N, Hayasaka H, Kikuta J, Scandella E, Ludewig B, Ishii S, Aoki J, Suematsu M, Ishii M, Takeda K, Jalkanen S, Miyasaka M, Umemoto E. eLife （2016）http://dx.doi.org/10.7554/eLife.10561
  14. The HIV-1 gp120/CXCR4 axis promotes CCR7 ligand-dependent CD4 T cell migration: CCR7 homo- and CCR7/CXCR4 hetero-oligomer formation as a possible mechanism for up-regulation of functional CCR7. *Hayasaka, H., Kobayashi, D., Yoshimura, H., Nakayama, E.E., Shioda, T., Miyasaka, M. PLoS ONE, 10：e0117454. (2015) https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0117454
  15. Lysophosphatidic acid receptors LPA4 and LPA6 differentially promote lymphocyte transmigration across high endothelial venules in lymph nodes. Hata, E., Sasaki N., Takeda A., Tohya K., Umemoto E., Akahoshi N., Ishii S., Bando K., Abe T., Kano K., Aoki JH., Hayasaka H., Miyasaka M. Int. Immunol., doi: 10.1093/intimm/dxv072 (2015)
  16. Dynamic changes in endothelial cell adhesion molecule nepmucin/CD300LG expression under physiological and pathological conditions. Umemoto, E., Takeda, A., Jin, S., Luo, Z., Nakahogi, N., Hayasaka, H., Lee, CM., Tanaka, T., Miyasaka, M. PLoS ONE, 8: e83681 (2013)
  17. FAK-related nonkinase is a multifunctional negative regulator of pulmonary fibrosis. Ding, Q., Cai, G-Q., Hu, M., Yang, Y., Zheng, A., Tang, Q., Gladson, CL., Hayasaka, H., Wu, H., You, Z., Southern, BD., Grove, LM., Rahaman, SO., Fang,H., Olman, MA. Am. J. Pathol., 182: 1572-1584. (2013)
  18. Constitutive lymphocyte transmigration across the basal lamina of high endothelial venules is regulated by the autotaxin/lysophosphatidic acid axis. Bai, Z., Cai, L., Umemoto, E., Takeda, A., Tohya, K., Komai, Y., Veeraveedu, PT., Hata, E., Sugiura, Y., Kubo, A., Suematsu, M., Hayasaka, H., Okudaira, S., Aoki, J., Tanaka T., Albers, HMHG., Ovaa, H., Miyasaka, M. J. Immunol., 190: 2036-2048. (2013)
  19. Constitutive plasmacytoid dendritic cell migration to the splenic white pulp is cooperatively regulated by CCR7- and CXCR4-mediated signaling. Umemoto, E., Otani, K Ikeno, T., Verjan Garcia N, Hayasaka, H., Bai, Z., Jang MH., Tanaka T., Ueda, K., Miyasaka, M. J. Immunol., 189: 191-199. (2012)
  20. Two-state conformations in the hyaluronan-binding domain regulate CD44 adhesiveness under flow condition. Ogino, S., Nishida, N., Umemoto, R., Suzuki, M., Takeda, M., Terasawa, H., Kitayama, J., Matsumoto, M., Hayasaka, H., Miyasaka, M., Shimada, I. Structure., 18: 649-656. (2010)

総説・紀要

  1. Nishizawa H, Kurowarabe K, Hayashi R, *Hayasaka H.：Real-time monitoring of B16 melanoma cell viability by the firefly luciferase-based bioluminescence.　Science and technology 32：5-11. (2021)
  2. 早坂　晴子：哺乳動物細胞における可溶型リンフォトキシン受容体タンパク質の発現　　理工学総合研究所研究報告　31：55-61. (2020)
  3. Miyasaka M, Hata E, Tohya K, Hayasaka H. Lymphocyte recirculation. Encyclopedia of Immunobiol., 3:486-492. (2016)
  4. Kellermayer Z, Hayasaka H, Kajtár B, Simon D, Robles EF, Martinez-Climent JA, Balogh P
    Divergence of vascular specification in visceral lymphoid organs - genetic determinants and differentiation checkpoints.　Int. Rev. Immunol. 35: 489-502 (2016)
  5. Umemoto, E., Hayasaka, H., Bai, Z., Cai, L., Yonekura, S., Peng, X., Takeda, A., Tohya, K., Miyasaka, M. Novel regulators of lymphocyte trafficking across high endothelial venules. Crit. Rev. Immunol., 31: 147-169. (2011)
  6. Hayasaka, H., Taniguchi, K., Fukai, S. Miyasaka, M. Neogenesis and development of the high endothelial venules that mediate lymphocyte trafficking. Cancer Sci., 101: 2302-2308. (2010)
  7. 小林　大地、宮坂　昌之、早坂　晴子：ケモカイン受容体の協働作用による効率的なリンパ球移動の誘導(2013) 生体の科学 64: 398-399.
  8. 早坂　晴子、岡田　麻里、白　忠彬、黒田　康嵩、吉田　淳一、宮坂　昌之：ケモカインによる白血球、癌細胞の生体内移動調節とケモカイン共働作用の関与 生化学 83: 930-937.　(2011)
  9. 黒田　康嵩、宮坂　昌之、早坂　晴子：がんとリンフォイドケモカイン　侵襲と免疫　20: 38-39. (2011)
  10. 早坂　晴子、宮坂　昌之：癌の進展、転移に関与するリンフォイドケモカイン　実験医学［増刊］29: 119-124. (2011)
  11. 白忠彬、蔡林君、梅本英司、竹田彰、池野嵩、秦枝里奈、早坂晴子、宮坂昌之: リンパ球トラフィキングをつかさどる新しい分子機構ー生理活性脂質産生酵素オートタキシンとその産物リゾフォスファチジン酸の役割 炎症と免疫　19: 8-13. (2011)
  12. 白　忠彬、蔡　林君、梅本英司、早坂晴子、宮坂昌之: 血管内皮細胞が発現する生理活性脂質産生酵素オートタキシン 実験医学［増刊］28: 144-152. (2010)

国際学会、シンポジウム

  1. Haruko Hayasaka: A cooperation of CCR7 and CXCR4 ligand chemokines regulate breast cancer cell invasion and migration towards lymphatic vessels.(2022 7th Global Insight Conference on Breast Cancer: Hybrid Event in Barcelona, Spain）
  2. Haruko Hayasaka, Daichi Kobayashi, Masataka Endo, Hironobu Hojo, Masayuki Miyasaka,CCR7 homo-dimerization regulates CCR7 ligand-dependent cell migration and signaling, ASCB/EMBO Meeting, 2017年, USA
  3. 早坂　晴子、宮坂　昌之：癌リンパ節転移研究における毛細リンパ管モデルの利用 (2014年　三次元生体組織構築シンポジウム：大阪大学中之島センター）
  4. Haruko Hayasaka, Daichi Kobayashi, Masayuki Miyasaka. Chemokine receptor oligomerization: a potential mechanism for regulating lymphocyte and cancer cell migration　（2013年 第51回日本生物物理学会シンポジウム：京都国際会議場）
  5. Haruko Hayasaka, Masayuki Miyasaka：Involvement of Dachshund1 in the development of the lymph node high endothelial venules. (2013年　新学術領域研究「四次元空間ダイナミクス」共催国際シンポジウム Synthetic Immunology Workshop)
  6. 白血球、癌細胞の生体内動態調節とケモカイン協働作用　早坂　晴子（2011年 新学術領域研究「過渡的複合体」公開シンポジウム：東京大学薬学部講堂）
  7. 早坂　晴子、吉村　洋美、白　忠彬、宮坂　昌之：ケモカインレセプターの準安定状態と細胞動態 (2010年 第10回日本蛋白質科学会年会　企画ワークショップ：札幌コンベンションセンター)
  8. Hayasaka H, Yoshimura H, Nakayama EE, Shioda T, Bai Z, Miyasaka M: The effects of HIV-1 gp120 on CCR7 ligand-induced human CD4 T cell trafficking.　(2010年 第14回　国際免疫学会）
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