業績一覧
- 書籍
- Diagnosis, Management and Modeling of Neurodevelopmental Disorders. The
Neuroscience of Development, Chapter 3, Chemical substances affecting neurodevelopmentISBN:
9780128179888 May, 2021 ELSEVIER
安全性薬理試験マニュアル 第２章第１節第2項 試験法の結果と評価
2009年9月 株式会社エル・アイ・シー
- 学術論文
- Detection of abnormal behaviors in prenatal Poly(I:C) exposed mice in a
group-rearing environment
Komada M., Kiriyama N., Sugiyama R., Harada K., Kawashita N
Congenital anomalies, 31 March 2024
[HP]
Epigenetics and Neuroinflammation Associated With Neurodevelopmental Disorders:
A Microglial Perspective
Komada M, Nishimura Y.
Front. Cell Dev. Biol., 12 May 2022
[HP]
Prenatal and postnatal bisphenol A exposure inhibits postnatal neurogenesis
in the hippocampal dentate gyrus.
Komada M, Nagao T, Kagawa N.
J Toxicol Sci. 2020;45(10):639-650. doi: 10.2131/jts.45.639.
PMID: 33012732 [Pubmed]
Postnatal di-2-ethylhexyl phthalate exposure affects hippocampal dentate
gyrus morphogenesis.
Komada M, Nagao T, Kagawa N.
J Appl Toxicol. 2020 Dec;40(12):1673-1682. doi: 10.1002/jat.4027. Epub
2020 Jul 7.
PMID: 32633424[Pubmed]
Elucidation of the mechanism of microglia transition in brain building
and its significance
Komada M
Impact 2019 Aug;(7):35-37.
doi: 10.21820/23987073.2019.7.35 [Link]
Bisphenol A exposure induces increased microglia and microglial related
factors in the murine embryonic dorsal telencephalon and hypothalamus.
Takahashi M, Komada M, Miyazawa K, Goto S, Ikeda Y.
Toxicol Lett. 2018 Mar 1;284:113-119. doi: 10.1016/j.toxlet.2017.12.010.
Epub 2017 Dec 14.
PMID: 29248573 [Pubmed]
Mechanisms underlying neuro-inflammation and neurodevelopmental toxicity
in the mouse neocortex following prenatal exposure to ethanol.
Komada M, Hara N, Kawachi S, Kawachi K, Kagawa N, Nagao T, Ikeda Y.
Sci Rep. 2017 Jul 10;7(1):4934. doi: 10.1038/s41598-017-04289-1.
PMID: 28694481[Pubmed]
Expression of Kisspeptin in Gonadotrope Precursors in the Mouse Pituitary
during Embryonic and Postnatal Development and in Adulthood.
Ikeda Y, Tagami A, Komada M, Takahashi M.
Neuroendocrinology. 2017;105(4):357-371. doi: 10.1159/000453398. Epub 2016
Nov 21.
PMID: 27871073 [Pubmed].
Prenatal exposure to di(2-ethylhexyl) phthalate impairs development of
the mouse neocortex.
Komada M, Gendai Y, Kagawa N, Nagao T.
Toxicol Lett. 2016 Sep 30;259:69-79. doi: 10.1016/j.toxlet.2016.07.019.
Epub 2016 Jul 27.
PMID: 27472966 [Pubmed]
Extraction of DNA from human embryos after long-term preservation in formalin
and Bouin's solutions.
Nagai M, Minegishi K, Komada M, Tsuchiya M, Kameda T, Yamada S.
Congenit Anom (Kyoto). 2016 May;56(3):112-8. doi: 10.1111/cga.12148.
PMID: 26662860[Pubmed]
Filamin A interacting protein plays a role in proper positioning of callosal
projection neurons in the cortex.
Yagi H, Oka Y, Komada M, Xie MJ, Noguchi K, Sato M.
Neurosci Lett. 2016 Jan 26;612:18-24. doi: 10.1016/j.neulet.2015.11.049.
Epub 2015 Dec 2.
PMID: 26655467 [Pubmed]
Involvement of SF-1 in neurogenesis and neuronal migration in the developing
neocortex.
Komada M, Takahashi M, Ikeda Y.
Neurosci Lett. 2015 Jul 23;600:85-90. doi: 10.1016/j.neulet.2015.06.005.
Epub 2015 Jun 9.
PMID: 26067405 [Pubmed]
DBZ regulates cortical cell positioning and neurite development by sustaining
the anterograde transport of Lis1 and DISC1 through control of Ndel1 dual-phosphorylation.
Okamoto M, Iguchi T, Hattori T, Matsuzaki S, Koyama Y, Taniguchi M, Komada
M, Xie MJ, Yagi H, Shimizu S, Konishi Y, Omi M, Yoshimi T, Tachibana T,
Fujieda S, Katayama T, Ito A, Hirotsune S, Tohyama M, Sato M.
J Neurosci. 2015 Feb 18;35(7):2942-58. doi: 10.1523/JNEUROSCI.5029-13.2015.
PMID: 25698733 [Pubmed]
Filamin A-interacting protein (FILIP) is a region-specific modulator of
myosin 2b and controls spine morphology and NMDA receptor accumulation.
Yagi H, Nagano T, Xie MJ, Ikeda H, Kuroda K, Komada M, Iguchi T, Tariqur
RM, Morikubo S, Noguchi K, Murase K, Okabe M, Sato M.
Sci Rep. 2014 Sep 15;4:6353. doi: 10.1038/srep06353.
PMID: 25220605[Pubmed].
Newborn mice exposed prenatally to bisphenol A show hyperactivity and defective
neocortical development.
Komada M, Itoh S, Kawachi K, Kagawa N, Ikeda Y, Nagao T.
Toxicology. 2014 Sep 2;323:51-60. doi: 10.1016/j.tox.2014.06.009. Epub
2014 Jun 20.
PMID: 24953688[Pubmed]
Neurobehavioral evaluation of mouse newborns exposed prenatally to low-dose
bisphenol A.
Nagao T, Kawachi K, Kagawa N, Komada M.
J Toxicol Sci. 2014 Apr;39(2):231-5. doi: 10.2131/jts.39.231.
PMID: 24646703 [Pubmed]
Smoothened controls cyclin D2 expression and regulates the generation of
intermediate progenitors in the developing cortex.
Komada M, Iguchi T, Takeda T, Ishibashi M, Sato M.
Neurosci Lett. 2013 Jun 28;547:87-91. doi: 10.1016/j.neulet.2013.05.006.
Epub 2013 May 13.
PMID: 23680462 [Pubmed]
Newly developed mouse newborn behavioral testing method for evaluating
the risk of neurotoxicity of environmental toxicants.
Nagao T, Kagawa N, Komada M.
J Appl Toxicol. 2013 Dec;33(12):1514-9. doi: 10.1002/jat.2802. Epub 2012
Aug 10.
PMID: 22887005 [Pubmed]
Developmental effects of oral exposure to diethylstilbestrol on mouse placenta.
Nagao T, Kagawa N, Saito Y, Komada M.
J Appl Toxicol. 2013 Nov;33(11):1213-21. doi: 10.1002/jat.2766. Epub 2012
Jun 25.
PMID: 22733484 [Pubmed]
Sonic hedgehog signaling coordinates the proliferation and differentiation
of neural stem/progenitor cells by regulating cell cycle kinetics during
development of the neocortex.
Komada M.
Congenit Anom (Kyoto). 2012 Jun;52(2):72-7. doi: 10.1111/j.1741-4520.2012.00368.x.
PMID: 22639991 Review. [Pubmed]
WAVE2-Abi2 complex controls growth cone activity and regulates the multipolar-bipolar
transition as well as the initiation of glia-guided migration.
Xie MJ, Yagi H, Kuroda K, Wang CC, Komada M, Zhao H, Sakakibara A, Miyata
T, Nagata K, Oka Y, Iguchi T, Sato M.
Cereb Cortex. 2013 Jun;23(6):1410-23. doi: 10.1093/cercor/bhs123. Epub
2012 May 22.
PMID: 22617848 [Pubmed]
Maternal bisphenol A oral dosing relates to the acceleration of neurogenesis
in the developing neocortex of mouse fetuses.
Komada M, Asai Y, Morii M, Matsuki M, Sato M, Nagao T.
Toxicology. 2012 May 16;295(1-3):31-8. doi: 10.1016/j.tox.2012.02.013.
Epub 2012 Mar 7.
PMID: 22426297[Pubmed]
Prenatal findings in congenital leukemia: a case report.
Sato Y, Izumi Y, Minegishi K, Komada M, Yamada S, Kakui K, Tatsumi K, Mikami
Y, Fujiwara H, Konishi I.
Fetal Diagn Ther. 2011;29(4):325-30. doi: 10.1159/000323582. Epub 2011
Feb 5.
PMID: 21293111 [Pubmed]
Methylnitrosourea induces neural progenitor cell apoptosis and microcephaly
in mouse embryos.
Komada M, Fujiyama F, Yamada S, Shiota K, Nagao T.
Birth Defects Res B Dev Reprod Toxicol. 2010 Jun;89(3):213-22. doi: 10.1002/bdrb.20245.
PMID: 20549696 [Pubmed]
Mice with altered myelin proteolipid protein gene expression display cognitive
deficits accompanied by abnormal neuron-glia interactions and decreased
conduction velocities.
Tanaka H, Ma J, Tanaka KF, Takao K, Komada M, Tanda K, Suzuki A, Ishibashi
T, Baba H, Isa T, Shigemoto R, Ono K, Miyakawa T, Ikenaka K.
J Neurosci. 2009 Jul 1;29(26):8363-71. doi: 10.1523/JNEUROSCI.3216-08.2009.
PMID: 19571127[Pubmed].
Elevated plus maze for mice.
Komada M, Takao K, Miyakawa T.
J Vis Exp. 2008 Dec 22;(22):1088. doi: 10.3791/1088.
PMID: 19229173 [Pubmed]
The cyst-branch difference in developing chick lung results from a different
morphogen diffusion coefficient.
Miura T, Hartmann D, Kinboshi M, Komada M, Ishibashi M, Shiota K.
Mech Dev. 2009 Mar-Apr;126(3-4):160-72. doi: 10.1016/j.mod.2008.11.006.
Epub 2008 Dec 6.
PMID: 19073251[Pubmed]
Hedgehog signaling is involved in development of the neocortex.
Komada M, Saitsu H, Kinboshi M, Miura T, Shiota K, Ishibashi M.
Development. 2008 Aug;135(16):2717-27. doi: 10.1242/dev.015891. Epub 2008
Jul 9.
PMID: 18614579 [Pubmed]
Expression of Fgf15 is regulated by both activator and repressor forms
of Gli2 in vitro.
Komada M, Saitsu H, Shiota K, Ishibashi M.
Biochem Biophys Res Commun. 2008 May 2;369(2):350-6. doi: 10.1016/j.bbrc.2008.02.015.
Epub 2008 Feb 13.
PMID: 18279667[Pubmed]
Embryogenesis of holoprosencephaly.
Shiota K, Yamada S, Komada M, Ishibashi M.
Am J Med Genet A. 2007 Dec 15;143A(24):3079-87. doi: 10.1002/ajmg.a.32020.
PMID: 17963261 Review. [Pubmed]
Sequential developmental changes in holoprosencephalic mouse embryos exposed
to ethanol during the gastrulation period.
Higashiyama D, Saitsu H, Komada M, Takigawa T, Ishibashi M, Shiota K.
Birth Defects Res A Clin Mol Teratol. 2007 Jul;79(7):513-23. doi: 10.1002/bdra.20367.
PMID: 17393481[Pubmed]
Signaling cascade coordinating growth of dorsal and ventral tissues of
the vertebrate brain, with special reference to the involvement of Sonic
Hedgehog signaling.
Ishibashi M, Saitsu H, Komada M, Shiota K.
Anat Sci Int. 2005 Mar;80(1):30-6. doi: 10.1111/j.1447-073x.2005.00096.x.
PMID: 15794128 Review. [Pubmed]
Expression of the mouse Fgf15 gene is directly initiated by Sonic hedgehog
signaling in the diencephalon and midbrain.
Saitsu H, Komada M, Suzuki M, Nakayama R, Motoyama J, Shiota K, Ishibashi
M.
Dev Dyn. 2005 Feb;232(2):282-92. doi: 10.1002/dvdy.20236.
PMID: 15614767 [Pubmed]
- 講義
- 担当科目
- [専門科目]
-講義-
■ 細胞生物学｜２年次後期
■ 発生生物学｜３年次前期
■ 生命科学序論｜１年次前期
■ 卒業研究ゼミナール｜3年次後期
■ 生命科学ゼミナールⅠ｜4年次前期
■ 生命科学ゼミナールⅡ｜4年次後期
■ 発生生物学特論｜大学院修士課程
■ 生体分子化学・環境化学総論｜大学院修士課程
■ 人類遺伝学演習｜大学院修士課程
■ 臨床遺伝学Ⅱ｜大学院修士課程
-実習・演習-
■ 生命科学実験｜２年次前期
■ 環境化学実験｜２年次後期
■ アドバンストリサーチ｜集中講義
■ 卒業研究｜4年次通年
■ 生物・環境化学特別研究｜大学院修士課程
[共通教養・基礎科目]
■ 基礎ゼミⅠ｜１年次前期
■ 基礎ゼミⅡ｜１年次後期
- 外部向け講義等
- [出張講義]
■「わたしの脳はいつできる？脳の形づくりと発達のメカニズム」（2019年度｜高校生）
■「『成長を続ける子供たちの脳－記憶の形成から考える曖昧な過去と効果的な勉強法－』」（2019年度｜一般向け）
※出張講義はパワーポイント・板書どちらにも対応しています。
[研究会]
■安全性評価研究会 第29回 夏の教育フォーラム 2021年9月10日＠オンライン
『マウスを用いた神経発生・発達毒性に対する個体・形態・分子レベルでのアプローチ』
■日本先天異常学会勉強会＠オンライン 世話人
・第１回『発生・発達期の環境要因による大脳皮質の形態形成異常が社会的行動に影響するメカニズムを、脳内炎症から紐解く』
- 卒業後の進路
- フジパン、年金事務所、近畿日本鉄道、小中学校教員
大学院進学（近畿大学）
- 共同研究
- [学内]
〇生命科学科
行動遺伝学研究室（加川尚 准教授・大塚愛理 助教）
計算生命科学研究室（川下理日人 講師）
分子機能制御研究室（島本茂 講師）
ゲノム科学研究室（木下善仁 講師）
[学外]
三重大学大学院 医学研究科 薬理学講座（西村有平 教授）