福嶋研究室のホームページ 
 
 
代表的な研究論文（1997～）  Research papers Kado, T., Kusakari, N., Tamaki, T., Murota, K., Tsujiuchi, T. and Fukushima, N. (2023) Oleic acid stimulates cell proliferation and BRD4–L-MYC-dependent glucose transporter transcription through PPARα activation in ovarian cancer cells. Biochem, Biophys. Res. Commun. Tamaki, T., Kagawa, N. and Fukushima, N. (2021) The Japanese lamprey (Lethenteron camtschaticum) expresses functional lysophosphatidic acid receptors. Biochem, Biophys. Res. Commun. 568 1-7. Nakayama, S., Adachi, M., Hatano, M., Inahata, N., Nagao, T. and Fukushima, N. (2021) Cytosine arabinoside induces phosphorylation of histone H2AX in hippocampal neurons via a noncanonical pathway. Neurochem. Int. 142, 104933 Fukushima, N. and Nagao T. (2018) Exposure to bisphenol A affects GABAergic neuron differentiation in neurosphere cultures. Neuroreport 29, 712-717. Tanaka, A., Yamamoto, A., Murota, K., Tsujiuchi, T., Iwamori, M., and Fukushima, N. (2017) Polyunsaturated fatty acids induce ovarian cancer cell death through ROS-dependent MAP kinase activation. Biochem, Biophys. Res. Commun. 493, 468-473. Ishii, S., Tsujiuchi, T., and Fukushima, N. (2017) Functional characterization of lysophosphatidic acid receptor 1 mutants identified in rat cancer tissues. Biochem, Biophys. Res. Commun. 486, 767-773. Morimoto, Y., Ishii, S., Ishibashi, J., Katoh, K., Tsujiuchi, T., Kagawa, N., and Fukushima, N. (2014) Functional lysophosphatidic acid receptors expressed in Oryzias latipes. Gene 551, 189-200. Nishimura, Y., Nagao, T. and Fukushima, N. (2014) Long-term pre-exposure of pheochromocytoma PC12 cells to endocrine-disrupting chemicals influences neuronal differentiation. Neurosci. Lett. 570, 1-4. Nishimura, Y., Nakai, Y., Tanaka, A., Nagao, T. and Fukushima, N. (2014) Long-term exposure of 3T3 fibroblast cells to endocrine disruptors alters sensitivity to oxidative injury. Cell Biol. Intl. 38. 868-874. Kuwata, S., Ohkubo, K., Kumamoto, S., Yamaguchi, N., Izuka, N., Murota, K., Tsujiuchi, T., Iwamori, M. and Fukushima, N. (2013) Extracellular lipid metabolism influences the survival of ovarian cancer cells. Biochem. Biophys. Res. Commun. 439, 280-284. Shibata, A., Tanabe, E., Inoue, S., Kitayoshi, M., Okimoto, S., Hirane, M., Araki, M., Fukushima, N. and Tsujiuchi, T. (2013) Hydrogen peroxide stimulates cell motile activity through LPA receptor-3 in liver epithelial WB-F344 cells. Biochem. Biophys. Res. Commun. 433, 317-321. Yoshikawa, K., Tanabe, E., Shibata, A., Inoue, S., Kitayoshi, M., Okimoto, S., Fukushima, N. and Tsujiuchi, T. (2013) Involvement of oncogenic K-ras on cell migration stimulated by lysophosphatidic acid receptor-2 in pancreatic cancer cells. Exp Cell Res. 319, 105-12. Furuta, D., Yamane, M., Tsujiuchi, T., Moriyama, R. and Fukushima, N. (2012) Lysophosphatidic acid induces neurite branch formation through LPA3. Mol. Cell. Neurosci. 50, 21-34. Fukushima, N., Furuta, D. and Tsujiuchi T. (2011) Coordinated interactions between actin and microtubules through crosslinkers in neurite retraction induced by lysophosphatidic acid. Neurochem. Intl. 59, 109-113. Yamane, M., Furuta, D. and Fukushima, N. (2010) Lysophosphatidic acid inluences initial neuronal polarity establishment. Neurosci. Lett. 480. 154-157. Obo Y., Yamada T., Furukawa M., Hotta M., Honoki K., Fukushima N., and Tsujiuchi T. (2009) Frequent mutations of lysophosphatidic acid receptor-1 gene in rat liver tumors. Mutat Res. 660, 47-50. Yamada T., Obo Y., Furukawa M., Hotta M., Yamasaki A., Honoki K., Fukushima N., and Tsujiuchi T. (2009) Mutations of lysophosphatidic acid receptor-1 gene during progression of lung tumors in rats. Biochem Biophys Res Commun. 378, 424-427. Shano, S., Moriyama, R., Chun, J. and Fukushima, N. (2008) Lysophosphatidic acid stimulates astrocyte proliferation through LPA1. Neurochem. Int. 52, 216-220. Shano, S., Hatanaka, K., Ninose, S., Moriyama, R., Tsujiuchi, T. and Fukushima, N. (2008) A lysophosphatidic acid receptor lacking the PDZ-binding domain is constitutively active and stimulates cell proliferation. Biochimica et Biophysica Acta Mol. Cell Res. 1783, 748–759. Fukushima, N., Shano, S., Moriyama, R. and Chun, J. (2007) Lysophosphatidic acid stimulates neuronal differentiation of cortical neuroblasts through the LPA1-Gi/o pathway. Neurochem. Int. 50, 302-307. Fukushima, N. and Morita, Y. (2006) Actomyosin-dependent microtubule rearrangement in lysophosphatidic acid-induced neurite remodeling of young cortical neurons. Brain Res. 1094. 65-75 Tsujiuchi, T., Shimizu, K., Onishi, M., Shigemura, M., Shano, S., Honoki, K., and Fukushima, N. (2006) Aberrant expressions of lysophosphatidic acid receptor genes in lung and liver tumors of rats. J. Toxicol. Pathol. 19, 137-141. Tsujiuchi, T., Shimizu, K., Onishi, M., Sugata, E., Fujii, H., Mori, T., Honoki, K., and Fukushima, N. (2006) Involvement of aberrant DNA methylation on reduced expression of lysophosphatidic acid receptor-1 gene in rat tumor cell lines. Biochem Biophys Res Commun. 349, 1151-1155. Sun, B., Nishihira, J., Suzuki, M., Fukushima, N., Ishibashi, T., Kondo, M., Sato, Y. and Todo, S. (2003) Induction of macrophage migration inhibitory factor by lysophosphatidic acid: relevance to tumor growth and angiogenesis. Int. J. Mol. Med. 12. 633-641. Fukushima, N., Ishii, I., Habara, Y., Allen, C. B. and Chun, J. (2002) Dual regulation of actin rearrangement through lysophosphatidic acid receptor in neuroblast cell lines; ACTIN DEPOLYMERIZATION BY Ca2+-α-ACTININ AND POLYMERIZATION BY RHO. Mol. Biol. Cell 13, 2692-2705. Fukushima, N., Weiner, J. A., Kaushal, D., Contos, J. J. A., Rehen, S., Kingsbury, M., Kim, K-Y. and Chun, J. (2002) Lysophosphatidic acid influences the morphology and motility of young, postmitotic cortical neurons. Mol. Cell. Neurosci. 20. 271-282. Contos, J. J. A., Ishii, I., Fukushima, N., Kingsbury, M. A., Ye, X., Kawamura, S., Brown, J. H. and Chun, J. (2002) Characterization of lpa2 (Edg4) and lpa1/lpa2 (Edg2/Edg4) lysophosphatidic acid receptor knockout mice: Signaling deficits without obvious phenotypic abnormality attributable to LPA2. Mol. Cell. Biol. 22. 6921-6929. Kimura, Y., Schmitt, A., Fukushima, N., Ishii, I., Kimura, H., Nebreda, A.R. and Chun, J. (2001) Two novel Xenopus homologs of mammalian LPA1/EDG-2 function as lysophosphatidic acid receptors in Xenopus oocytes and mammalian cells. J. Biol. Chem. 276, 15208-15215. Fukushima, N., Weiner, J. A.*, Contos, J. A., Scherer, S. S. and Chun, J. (2001) Regulation of Schwann cell morphology and adhesion by receptor-mediated lysophosphatidic acid signaling. J. Neurosci. 21. 7069-7078. Ishii, I., Contos, J. J. A., Fukushima, N. and Chun, J. (2000) Functional comparisons of the lysophosphatidic acid receptors, LPA1/VZG-1/EDG2, LPA2/EDG-4 and LPA3/EDG7 in neuronal cell lines using a retrovirus expression system. Mol. Pharmacol. 58, 895-902. Fukushima, N., Weiner, J. A. and Chun, J. (2000) Lysophosphatidic acid (LPA) is a novel extracellular regulator of cortical neuroblast morphology. Dev. Biol. 228, 6-18. Contos, J.J.A., Fukushima, N., Weiner, J.A., Kaushal, D. and Chun, J. (2000) Requirement for the lpA1 lysophosphatidic acid receptor gene in normal suckling behavior. Proc. Natl. Acad. Sci. USA. 97, 13384-13389. Dubin, A. E., Bahnson, T., Weiner, J. A., Fukushima, N. and Chun, J. (1999) Lysophosphatidic acid (LPA) stimulates neurotransmitter-like conductance changes that precede GABA and L-glutamate in early, presumptive cortical neuroblasts. J. Neurosci. 19: 1371-1381. Zhang, G., Contos, J. J. A., Weiner, J. A., Fukushima, N., and Chun, J. (1999) Comparative analysis of three murine G-protein coupled receptors activated by sphingosine-1-phosphate. Gene 227: 89-99. Fukushima, N., Kimura, Y. and Chun, J. (1998) A single receptor encoded by vzg-1/lpA1/edg-2 couples to G-proteins and mediates multiple cellular responses to lysophosphatidic acid (LPA). Proc. Natl. Acad. Sci. USA 95: 6151-6156.